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Our research concentrates on the biology of skeletal stem cells that are the basis for the high regenerative capacities of skeletal tissues and that are potentially deficient in various musculoskeletal diseases and disorders. We aim to elucidate the mechanisms of stem cell activation in their complex tissue environment in development, disease and repair employing genetic mouse models, genomics and cellular approaches. We focus on the periosteum, the tissue at the outer surface of bone and skeletal muscle adjacent to bone, that also plays essential roles in bone regeneration.
We are part of the Team "Biology of the Neuro-Muscular System" headed by Frédéric Relaix at IMRB
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